KLRK1 - killer cell lectin like receptor K1 Gene
Also Known as KLR; CD314; NKG2D; NKG2-D; D12S2489E
Species: Homo sapiens
About KLRK1
This gene has 5 transcripts (splice variants), 129 orthologues and 23 paralogues. Broad expression in spleen (RPKM 28.6), lymph node (RPKM 22.6) and 16 other tissues.
Summary
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010]
KLRK1 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_007360.4 | NP_031386.2 | NKG2-D type II integral membrane protein |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
10426993 | GOA |
| enables signaling receptor activity |
IDA
IDA: Inferred from direct assay
|
17562706 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in natural killer cell mediated cytotoxicity |
IDA
IDA: Inferred from direct assay
|
17562706 | GOA |
| involved in negative regulation of GTPase activity |
IDA
IDA: Inferred from direct assay
|
22585739 | GOA |
| involved in negative regulation of natural killer cell chemotaxis |
IDA
IDA: Inferred from direct assay
|
22585739 | GOA |
| involved in positive regulation of natural killer cell mediated cytotoxicity |
IDA
IDA: Inferred from direct assay
|
15294961 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cell surface |
IDA
IDA: Inferred from direct assay
|
10426994 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
17562706 | GOA |
KLRK1 Protein Structure
Lectin_C: Lectin C-type domain (116 - 212)
- 0
- 100
- 200
- 216 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
NKG2-D type II integral membrane protein |
|
Recombinant KLRK1 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P70688 | NKG2D/CD314 Protein, Human (HEK293, His) | P26718 (F78-V216) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P72018 | NKG2D/CD314 Protein, Human (HEK293, Fc) | P26718 (F78-V216) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P73319 | NKG2D/CD314 Protein, Human (sf9, His) | P26718 (F78-V216) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P76512 | NKG2D/CD314 Protein, Human (CHO, Fc) | P26718 (F78-V216) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P78183 | NKG2D/CD314 Protein, Human (Biotinylated, HEK293, His-Avi) | P26718 (F78-V216) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P78498 | NKG2D/CD314 Protein, Human (HEK293, Fc-Flag) | P26718 (F78-V216) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P78500 | NKG2D/CD314 Protein, Human (HEK293, His-Avi) | P26718 (F78-V216) | ≥ 95%, as determined by Bis-Tris PAGE. |
KLRK1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P84221 | CD314/NKG2D Antibody (YA3918) | WB, FC, ELISA | Human, Rat |
| HY-P84221A | CD314/NKG2D Antibody (YA3918)(PBS only) | WB, FC, ELISA | Human, Rat |
| HY-P84986 | CD314/NKG2D Antibody (YA4678) | ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Cowpox |
|
|
| Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia |
|
|
| Alopecia Areata |
|
|
| Nk Cell Deficiency |
|
|
| Celiac Disease 1 |
|
|
| Echinococcosis |
|
|
| Alopecia Universalis Congenita |
|
|
| Nasopharyngeal Carcinoma |
|
|
| Autoimmune Disease |
|
|
| Pancreatic Cancer |
|
|
| Colorectal Cancer |
|
|
| Viral Infectious Disease |
|
|
| Monkeypox |
|
|
| Rheumatoid Arthritis |
|
|
| Melanoma |
|
|
| Combined Immunodeficiency |
|
|
| Myeloma, Multiple |
|
|
| Hepatocellular Carcinoma |
|
|
| Human Cytomegalovirus Infection |
|
|
| Gastric Cancer |
|
|
| Bronchiectasis 1 |
|
|
| Systemic Lupus Erythematosus |
|
|
| Leukemia, Chronic Myeloid |
|
|
| Neuroblastoma |
|
|
| Ovarian Cancer |
|
|
| Immune Deficiency Disease |
|
|
| Behcet Syndrome |
|
|
| Leukemia, Acute Myeloid |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | KLRK1 | MGD | MGI:1196250 |
| Rattus norvegicus | KLRK1 | RGD | RGD:3180 |
| Canis familiaris | KLRK1 | VGNC | VGNC:54966 |
| Others | KLRK1 | NCBI |